Peste des petits ruminants
نویسندگان
چکیده
Peste des petits ruminants virus causes a highly infectious disease of small ruminants that is endemic across Africa, the Middle East and large regions of Asia. The virus is considered to be a major obstacle to the development of sustainable agriculture across the developing world and has recently been targeted by the World Organisation for Animal Health (OIE) and the Food and Agriculture Organisation (FAO) for eradication with the aim of global elimination of the disease by 2030. Fundamentally, the vaccines required to successfully achieve this goal are currently available, but the availability of novel vaccine preparations to also fulfill the requisite for differentiation between infected and vaccinated animals (DIVA) may reduce the time taken and the financial costs of serological surveillance in the later stages of any eradication campaign. Here, we overview what is currently known about the virus, with reference to its origin, updated global circulation, molecular evolution, diagnostic tools and vaccines currently available to combat the disease. Further, we comment on recent developments in our knowledge of various recombinant vaccines and on the potential for the development of novel multivalent vaccines for small ruminants.
منابع مشابه
Cloning of fusion (F) protein gene of peste des petits ruminants virus (PPRV) in secretory Pichia pastoris vector
With advent and development of DNA recombinant technology and advantages of p. pastoris expression system, fusion (F) protein of PPRV expression, because of effective immunodominant role could be an appropriate candidate for production of recombinant vaccine against PPR disease. In this study, F gene of PPRV Nigeria 75/1 strain (1637 bp) was amplified using RT-PCR and purified. It was then cl...
متن کاملSeroprevalence Study of Peste Des Petits Ruminants in Sheeps of Shabestar, Iran
Background Peste des petits ruminants (PPR) disease is one of the most important viral infections in sheep and goats that is caused by a morbillivirus from the paramixoviridae family, causing lesions in the gastrointestinal tract and respiratory tract. Methods In the present study, 250 blood samples were taken from the jugular vein of the apparently healthy and diseased sheep with common sympto...
متن کاملCharacterization of Peste des Petits Ruminants Virus, Eritrea, 2002–2011
Figure. Distribution of ruminants in Eritrea with peste des petits ruminants virus infection, 2003–2011. Colored circles indicate regions from which tissue samples were collected from goats and sheep during outbreaks of peste des petits ruminants; nucleotide sequences for the samples were determined and analyzed.
متن کاملComplete Genome Sequence of a Lineage I Peste des Petits Ruminants Virus Isolated in 1969 in West Africa
We report the complete genome sequence of a lineage I peste des petits ruminants virus (E32/1969) isolated in a Senegalese laboratory in 1969. This is the earliest peste des petits ruminants virus of any lineage sequenced to date and only the second lineage I virus available in public databases.
متن کاملPeste des Petits Ruminants Virus in Heilongjiang Province, China, 2014
During March 25-May 5, 2014, we investigated 11 outbreaks of peste des petits ruminants in Heilongjiang Province, China. We found that the most likely source of the outbreaks was animals from livestock markets in Shandong. Peste des petits ruminants viruses belonging to lineages II and IV were detected in sick animals.
متن کامل